SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland.

@article{Fauquier2008SOX2expressingPC,
  title={SOX2-expressing progenitor cells generate all of the major cell types in the adult mouse pituitary gland.},
  author={Teddy Fauquier and Karine Rizzoti and Mehul T Dattani and Robin Lovell-Badge and Iain C. A. F. Robinson},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 8},
  pages={2907-12}
}
The pituitary gland adapts the proportion of each of its endocrine cell types to meet differing hormonal demands throughout life. There is circumstantial evidence that multipotent adult progenitor cells contribute to this plasticity, but these cells have not been identified. Here, we describe a small (<0.05%) population of progenitor cells in the adult pituitary gland. We show that these cells express SOX2, a marker of several early embryonic progenitor and stem cell types, and form… CONTINUE READING
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