SOX2 and cancer: current research and its implications in the clinic

@inproceedings{Weina2014SOX2AC,
  title={SOX2 and cancer: current research and its implications in the clinic},
  author={Kasia M. Weina and Jochen Utikal},
  booktitle={Clinical and translational medicine},
  year={2014}
}
SOX2 is a gene that encodes for a transcription factor belonging to the SOX gene family and contains a high-mobility group (HMG) domain, which permits highly specific DNA binding. Consequently, SOX2 functions as an activator or suppressor of gene transcription. SOX2 has been described as an essential embryonic stem cell gene and moreover, a necessary factor for induced cellular reprogramming. SOX2 research has only recently switched focus from embryogenesis and development to SOX2's function in… CONTINUE READING