SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling

@article{Thu2014SOX15IA,
  title={SOX15 is a candidate tumor suppressor in pancreatic cancer with a potential role in Wnt/β-catenin signaling},
  author={Kelsie L. Thu and Nikolina Radulovich and Daiana D. Becker-Santos and Larissa Pikor and Andrea L. Pusic and William W. Lockwood and Wan L. Lam and Ming-Sound Tsao},
  journal={Oncogene},
  year={2014},
  volume={33},
  pages={279-288}
}
Pancreatic cancer is among the top five deadliest cancers in developed countries. Better knowledge of the molecular mechanisms contributing to its tumorigenesis is imperative to improve patient prognosis. Identification of novel tumor suppressor genes (TSGs) in pancreatic cancer will reveal new mechanisms of pathway deregulation and will ultimately help improve our understanding of this aggressive disease. According to Knudson’s two-hit model, TSGs are classically disrupted by two concerted… CONTINUE READING