SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome.

@article{Sabater2008SOX1AA,
  title={SOX1 antibodies are markers of paraneoplastic Lambert-Eaton myasthenic syndrome.},
  author={Lidia Sabater and M Titulaer and A Saiz and J Verschuuren and Ali O. G{\"u}re and Francesc Graus},
  journal={Neurology},
  year={2008},
  volume={70 12},
  pages={924-8}
}
BACKGROUND/OBJECTIVE We reported that 43% of patients with Lambert-Eaton myasthenic syndrome (LEMS) and small cell lung cancer (SCLC) had an antibody called anti-glial nuclear antibody (AGNA), defined by the immunoreaction with the nuclei of the Bergmann glia of the cerebellum. This study was undertaken to identify the antigen recognized by AGNA and to confirm the association with paraneoplastic LEMS in a larger series. METHODS We probed a fetal brain cDNA library with AGNA-positive sera. The… CONTINUE READING
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Prognosis and autoimmunity in Lambert-Eaton syndrome

  • W. Schmalstieg, D. Lachance, V. Lennon
  • Neurology 68 (Suppl 1):A107,
  • 2007

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