SOS-NMR: a saturation transfer NMR-based method for determining the structures of protein-ligand complexes.

@article{Hajduk2004SOSNMRAS,
  title={SOS-NMR: a saturation transfer NMR-based method for determining the structures of protein-ligand complexes.},
  author={Philip J. Hajduk and Jamey C. Mack and Edward T. Olejniczak and Chang Hee Park and Peter J Dandliker and Bruce A Beutel},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 8},
  pages={2390-8}
}
An NMR-based alternative to traditional X-ray crystallography and NMR methods for structure-based drug design is described that enables the structure determination of ligands complexed to virtually any biomolecular target regardless of size, composition, or oligomeric state. The method utilizes saturation transfer difference (STD) NMR spectroscopy performed on a ligand complexed to a series of target samples that have been deuterated everywhere except for specific amino acid types. In this way… CONTINUE READING

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