SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

@article{Reiche2010SORLASORL1FI,
  title={SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.},
  author={Juliane Reiche and Franziska Theilig and Fatema H. Rafiqi and Anne-Sophie Carlo and Daniel Militz and Kerim Mutig and Mihail Todiras and Erik Ils\o Christensen and David H Ellison and Michael Bader and Anders Nykjaer and Sebastian Bachmann and Dario Alessi and Thomas E. Willnow},
  journal={Molecular and cellular biology},
  year={2010},
  volume={30 12},
  pages={3027-37}
}
Proper control of NaCl excretion in the kidney is central to bodily functions, yet many mechanisms that regulate reabsorption of sodium and chloride in the kidney remain incompletely understood. Here, we identify an important role played by the intracellular sorting receptor SORLA (sorting protein-related receptor with A-type repeats) in functional activation of renal ion transporters. We demonstrate that SORLA is expressed in epithelial cells of the thick ascending limb (TAL) of Henle's loop… CONTINUE READING

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