SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population.

@article{Wang2012SORCS1AA,
  title={SORCS1 and APOE polymorphisms interact to confer risk for late-onset Alzheimer's disease in a Northern Han Chinese population.},
  author={Hui-Fu Wang and Jintai Yu and Wei Zhang and Wei Wang and Qiuli Liu and Xiao-Ying Ma and Hua-Min Ding and Lorwai Tan},
  journal={Brain research},
  year={2012},
  volume={1448},
  pages={111-6}
}
Sortilin-related VPS domain containing receptor 1 (SORCS1), is located on chromosome 10q23.3, a chromosomal region of interest in Alzheimer's disease (AD) defined by many genome-wide and chromosome10-specific studies. Recently, three intronic variants (rs12571141, rs17277986 and rs6584777) within SORCS1 were reported to be associated with AD in Caucasian. In order to assess the involvement of the SORCS1 polymorphisms in the progression of late-onset AD (LOAD), we conducted an independent… CONTINUE READING

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