SORCS1 alters amyloid precursor protein processing and variants may increase Alzheimer's disease risk.

Abstract

OBJECTIVE Sorting mechanisms that cause the amyloid precursor protein (APP) and the β-secretases and γ-secretases to colocalize in the same compartment play an important role in the regulation of Aβ production in Alzheimer's disease (AD). We and others have reported that genetic variants in the Sortilin-related receptor (SORL1) increased the risk of AD… (More)
DOI: 10.1002/ana.22308

Topics

10 Figures and Tables