SOD2 to SOD1 switch in breast cancer.

  title={SOD2 to SOD1 switch in breast cancer.},
  author={Luena Papa and Mary Hahn and Ellen L. Marsh and Bradley S Evans and Doris Germain},
  journal={The Journal of biological chemistry},
  volume={289 9},
Cancer cells are characterized by elevated levels of reactive oxygen species, which are produced mainly by the mitochondria. The dismutase SOD2 localizes in the matrix and is a major antioxidant. The activity of SOD2 is regulated by the deacetylase SIRT3. Recent studies indicated that SIRT3 is decreased in 87% of breast cancers, implying that the activity of SOD2 is compromised. The resulting elevation in reactive oxygen species was shown to be essential for the metabolic reprograming toward… CONTINUE READING
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