SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy.

@article{Vincent2007SOD2PN,
  title={SOD2 protects neurons from injury in cell culture and animal models of diabetic neuropathy.},
  author={Andrea M. Vincent and James William Russell and Kelli A. Sullivan and Carey Backus and John M. Hayes and Lisa L. McLean and Eva L. Feldman},
  journal={Experimental neurology},
  year={2007},
  volume={208 2},
  pages={216-27}
}
Hyperglycemia-induced oxidative stress is an inciting event in the development of diabetic complications including diabetic neuropathy. Our observations of significant oxidative stress and morphological abnormalities in mitochondria led us to examine manganese superoxide dismutase (SOD2), the enzyme responsible for mitochondrial detoxification of oxygen radicals. We demonstrate that overexpression of SOD2 decreases superoxide (O(2)(-)) in cultured primary dorsal root ganglion (DRG) neurons and… CONTINUE READING