SOD2 functions downstream of Sch9 to extend longevity in yeast.

@article{Fabrizio2003SOD2FD,
  title={SOD2 functions downstream of Sch9 to extend longevity in yeast.},
  author={Paola Fabrizio and Lee-Loung Liou and Vanessa N. Moy and Alberto Diaspro and Joan Selverstone Valentine and Edith Butler Gralla and Valter D Longo},
  journal={Genetics},
  year={2003},
  volume={163 1},
  pages={
          35-46
        }
}
Signal transduction pathways inactivated during periods of starvation are implicated in the regulation of longevity in organisms ranging from yeast to mammals, but the mechanisms responsible for life-span extension are poorly understood. Chronological life-span extension in S. cerevisiae cyr1 and sch9 mutants is mediated by the stress-resistance proteins Msn2/Msn4 and Rim15. Here we show that mitochondrial superoxide dismutase (Sod2) is required for survival extension in yeast. Deletion of SOD2… CONTINUE READING

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