SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.

@article{Homma2013SOD1AA,
  title={SOD1 as a molecular switch for initiating the homeostatic ER stress response under zinc deficiency.},
  author={Kengo Homma and Takao Fujisawa and Naomi Tsuburaya and Namiko Yamaguchi and Hisae Kadowaki and Kohsuke Takeda and Hideki Nishitoh and A. Matsuzawa and Isao Naguro and Hidenori Ichijo},
  journal={Molecular cell},
  year={2013},
  volume={52 1},
  pages={75-86}
}
Zinc is an essential trace element, and impaired zinc homeostasis is implicated in the pathogenesis of various human diseases. However, the mechanisms cells use to respond to zinc deficiency are poorly understood. We previously reported that amyotrophic lateral sclerosis (ALS)-linked pathogenic mutants of SOD1 cause chronic endoplasmic reticulum (ER) stress through specific interactions with Derlin-1, which is a component of the ER-associated degradation machinery. Moreover, we recently… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 54 references

Similar Papers

Loading similar papers…