SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments

@article{Joyce2011SOD1AT,
  title={SOD1 and TDP-43 animal models of amyotrophic lateral sclerosis: recent advances in understanding disease toward the development of clinical treatments},
  author={Peter I. Joyce and Pietro Fratta and Elizabeth Fisher and Abraham Acevedo-Arozena},
  journal={Mammalian Genome},
  year={2011},
  volume={22},
  pages={420-448}
}
Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease with no cure. Breakthroughs in understanding ALS pathogenesis came with the discovery of dominant mutations in the superoxide dismutase 1 gene (SOD1) and other genes, including the gene encoding transactivating response element DNA binding protein-43 (TDP-43). This has led to the creation of animal models to further our understanding of the disease and identify a number of ALS-causing mechanisms, including mitochondrial… CONTINUE READING
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