SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses.

@article{Orr2007SOCS3TS,
  title={SOCS3 targets Siglec 7 for proteasomal degradation and blocks Siglec 7-mediated responses.},
  author={Selinda J Orr and Nuala M Morgan and Richard J. Buick and C. A. Richard Boyd and Joanne Elliott and James F. Burrows and Caroline A. Jefferies and Paul R. Crocker and James D. Johnston},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 6},
  pages={3418-22}
}
CD33-related Siglecs (sialic acid-binding immunoglobulin-like lectins) 5-11 are inhibitory receptors that contain a membrane proximal ITIM (immunoreceptor tyrosine-based inhibitory motif) (I/V/L/)XYXX(L/V), which can recruit SHP-1/2. However, little is known about the regulation of these receptors. SOCS3 (suppressor of cytokine signaling 3) is up-regulated during inflammation and competes with SHP-1/2 for binding to ITIM-like motifs on various cytokine receptors resulting in inhibition of… CONTINUE READING

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