SOCS3 negatively regulates IL-6 signaling in vivo

  title={SOCS3 negatively regulates IL-6 signaling in vivo},
  author={Ben A Croker and Danielle L. Krebs and Jian Gong Zhang and Samuel Wormald and Tracy A Willson and Edouard G. Stanley and Lorraine Robb and Christopher J. Greenhalgh and Irmgard F{\"o}rster and Bj{\"o}rn E Clausen and Nicos A. Nicola and Donald Metcalf and Douglas J. Hilton and Andrew W Roberts and Warren S. Alexander},
  journal={Nature Immunology},
Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is involved in regulating this signaling, we have used conditional gene targeting to generate mice lacking Socs3 in the liver or in macrophages. We show that Socs3 deficiency results in prolonged activation of signal transducer and activator of transcription 1 (STAT1) and STAT3 after IL-6 stimulation but normal activation… CONTINUE READING
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