SOCS3 negatively regulates IL-6 signaling in vivo

@article{Croker2003SOCS3NR,
  title={SOCS3 negatively regulates IL-6 signaling in vivo},
  author={Ben A Croker and Danielle L. Krebs and Jian Gong Zhang and Samuel Wormald and Tracy A Willson and Edouard G. Stanley and Lorraine Robb and Christopher J. Greenhalgh and Irmgard F{\"o}rster and Bj{\"o}rn E Clausen and Nicos A. Nicola and Donald Metcalf and Douglas J. Hilton and Andrew W Roberts and Warren S. Alexander},
  journal={Nature Immunology},
  year={2003},
  volume={4},
  pages={540-545}
}
Members of the suppressor of cytokine signaling (SOCS) family are potentially key physiological negative regulators of interleukin-6 (IL-6) signaling. To examine whether SOCS3 is involved in regulating this signaling, we have used conditional gene targeting to generate mice lacking Socs3 in the liver or in macrophages. We show that Socs3 deficiency results in prolonged activation of signal transducer and activator of transcription 1 (STAT1) and STAT3 after IL-6 stimulation but normal activation… CONTINUE READING
Highly Influential
This paper has highly influenced 23 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 325 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 37 references

SOCS 3 regulates the plasticity of gp 130 signaling

  • R. Lang
  • Nat . Immunol . advance online publication , 18…
  • 2003

Essential role of STAT 3 in the control of the acutephase response as revealed by inducible gene inactivation in the liver

  • T. Alonzi
  • Mol . Cell . Biol .
  • 2001

Similar Papers

Loading similar papers…