SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.

@article{Lindeman2001SOCS1DR,
  title={SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.},
  author={G J Lindeman and Sergio Wittlin and Hania Lada and Matthew J. Naylor and Manuel Santamar{\'i}a and Jian Gang Zhang and Robyn Starr and Douglas J. Hilton and Warren S. Alexander and Christopher J Ormandy and Jane Visvader},
  journal={Genes & development},
  year={2001},
  volume={15 13},
  pages={1631-6}
}
Prolactin is essential for proliferation and differentiation of the developing mammary gland. We have explored a role for Suppressor of Cytokine Signaling 1 (SOCS1) as a modulator of the prolactin response using mice deficient in SOCS1, which were rescued from neonatal death by deletion of the Interferon gamma (IFN gamma) gene. SOCS1(-/-)/IFN gamma(-/-) mice exhibited accelerated lobuloalveolar development in the mammary gland during late pregnancy and precocious lactation. Significantly, the… CONTINUE READING

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