SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes.

  title={SOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes.},
  author={Yirui Gui and Mehdi Yeganeh and Sheela Ramanathan and Chantal Leblanc and V{\'e}ronique Pomerleau and Gerardo Ferbeyre and Caroline Saucier and Subburaj Ilangumaran},
  journal={Journal of hepatology},
  volume={55 6},
BACKGROUND & AIMS Frequent repression of the Socs1 (suppressor of cytokine signaling 1) gene in hepatocellular carcinoma (HCC) and increased susceptibility of SOCS1-deficient mice to hepatocarcinogens suggest a tumor suppressor role for SOCS1 in the liver, but the underlying mechanisms remain unclear. Here we investigated the role of SOCS1 in regulating hepatocyte proliferation following partial hepatectomy and HGF stimulation. METHODS Because Socs1(-/-) mice die prematurely due to… CONTINUE READING


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Publications referenced by this paper.
Showing 1-10 of 36 references

Liver regeneration: from myth to mechanism

Nature Reviews Molecular Cell Biology • 2004
View 19 Excerpts
Highly Influenced

Hepatocyte growth factor/c-met signaling pathway is required for efficient liver regeneration and repair.

Proceedings of the National Academy of Sciences of the United States of America • 2004
View 4 Excerpts
Highly Influenced

Liver regeneration.

Journal of hepatology • 2000
View 1 Excerpt
Highly Influenced

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