SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function

@inproceedings{Ahmed2015SOCS1MA,
  title={SOCS1 Mimetics and Antagonists: A Complementary Approach to Positive and Negative Regulation of Immune Function},
  author={Chulbul M. I. Ahmed and Joseph P Larkin and Howard M Johnson},
  booktitle={Front. Immunol.},
  year={2015}
}
Suppressors of cytokine signaling (SOCS) are inducible intracellular proteins that play essential regulatory roles in both immune and non-immune function. Of the eight known members, SOCS1 and SOCS3 in conjunction with regulatory T cells play key roles in regulation of the immune system. Molecular tools such as gene transfections and siRNA have played a major role in our functional understanding of the SOCS proteins where a key functional domain of 12-amino acid residues called the kinase… CONTINUE READING

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