SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade.

  title={SOCS up-regulation mobilizes autologous stem cells through CXCR4 blockade.},
  author={Oscar M Pello and Mar{\'i}a del Carmen Moreno-Ortiz and Jos{\'e} Miguel Rodr{\'i}guez-Frade and Laura Mart{\'i}nez-Mu{\~n}oz and Daniel Lucas and Lucio G{\'o}mez and Pilar de Lucas and Enrique Samper and Miguel Aracil and Carlos Martinez and Antonio Bernad and Mario Mellado},
  volume={108 12},
The chemokine CXCL12 influences self-renewal and differentiation of hematopoietic stem cell precursors in bone marrow by directing them toward specific stromalcell components. CXCL12 up-regulates members of the SOCS family through JAK/STAT activation, a mechanism that attenuates chemokine responses. SOCS expression may thus modulate retention of hematopoietic precursors (Sca-1(+) c-Kit(+)Lin(-) cells) in bone marrow. We show that in bovine growth hormone transgenic mice and in growth hormone… CONTINUE READING
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A novel 3936 PELLO et al BLOOD

  • A Yoshimura, T Ohkubo, T Kiguchi
  • VOLUME 108,
  • 2006

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