SOCS proteins: negative regulators of cytokine signaling.

@article{Krebs2001SOCSPN,
  title={SOCS proteins: negative regulators of cytokine signaling.},
  author={Danielle L. Krebs and Douglas J. Hilton},
  journal={Stem cells},
  year={2001},
  volume={19 5},
  pages={
          378-87
        }
}
Cytokines regulate the growth and differentiation of cells by binding to cell-surface receptors and activating intracellular signal transduction cascades such as the JAK-STAT pathway. Cytokine signaling is negatively regulated with respect to both magnitude and duration, and it is now clear that the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS) contributes significantly to this process. Transcripts encoding CIS, SOCS1, SOCS2, and SOCS3 are upregulated in… CONTINUE READING
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