SOCS Proteins: Negative Regulators of Cytokine Signaling

@article{Krebs2001SOCSPN,
  title={SOCS Proteins: Negative Regulators of Cytokine Signaling},
  author={Danielle L. Krebs and Douglas J. Hilton},
  journal={STEM CELLS},
  year={2001},
  volume={19}
}
Cytokines regulate the growth and differentiation of cells by binding to cell‐surface receptors and activating intracellular signal transduction cascades such as the JAK‐STAT pathway. Cytokine signaling is negatively regulated with respect to both magnitude and duration, and it is now clear that the suppressor of cytokine signaling (SOCS) family of proteins (SOCS1‐SOCS7 and CIS) contributes significantly to this process. Transcripts encoding CIS, SOCS1, SOCS2, and SOCS3 are upregulated in… 

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