SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.

@article{Cohney1999SOCS3IT,
  title={SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation.},
  author={Solomon J Cohney and D. C. van de Sanden and Nicolas A Cacalano and Akihiko Yoshimura and Alice L. F. Mui and Thi Sau Migone and J D Johnston},
  journal={Molecular and cellular biology},
  year={1999},
  volume={19 7},
  pages={4980-8}
}
Members of the recently discovered SOCS/CIS/SSI family have been proposed as regulators of cytokine signaling, and while targets and mechanisms have been suggested for some family members, the precise role of these proteins remains to be defined. To date no SOCS proteins have been specifically implicated in interleukin-2 (IL-2) signaling in T cells. Here we report SOCS-3 expression in response to IL-2 in both T-cell lines and human peripheral blood lymphocytes. SOCS-3 protein was detectable as… CONTINUE READING

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