SOCS-1 regulates IL-15–driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential

@article{Davey2005SOCS1RI,
  title={SOCS-1 regulates IL-15–driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential},
  author={Gayle M Davey and Robyn Starr and Ann L. Cornish and J. Theodore Burghardt and Warren S. Alexander and Francis Robert Carbone and Charles D. Surh and William R Heath},
  journal={The Journal of Experimental Medicine},
  year={2005},
  volume={202},
  pages={1099 - 1108}
}
Mice that are deficient in suppressor of cytokine signaling-1 (SOCS-1) succumb to neonatal mortality that is associated with extensive cellular infiltration of many tissues. T cells seem to be necessary for disease, which can be alleviated largely by neutralizing interferon-gamma. Examining T cell receptor (TCR) specificity shows that even monospecific T cells can mediate disease in SOCS-1-deficient mice, although disease onset is substantially faster with a polyclonal T cell repertoire. A… CONTINUE READING

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