SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29.

@article{Brand2005SOCS1IE,
  title={SOCS-1 inhibits expression of the antiviral proteins 2',5'-OAS and MxA induced by the novel interferon-lambdas IL-28A and IL-29.},
  author={Stephan Brand and Kathrin Zitzmann and Julia Dambacher and Florian Beigel and Torsten Olszak and George Vlotides and S{\"o}ren T. Eichhorst and Burkhard J. G{\"o}ke and Helmut Michael Diepolder and Christoph Josef Auernhammer},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={331 2},
  pages={543-8}
}
Recently, we have shown that SOCS-1/3 overexpression in hepatic cells abrogates signaling of type I interferons (IFN) which may contribute to the frequently observed IFN resistance of hepatitis C virus (HCV). IFN-lambdas (IL-28A/B and IL-29), a novel group of IFNs, also efficiently inhibit HCV replication in vitro with potentially less hematopoietic side effects than IFN-alpha because of limited receptor expression in hematopoietic cells. To further evaluate the potential of IFN-lambdas in… CONTINUE READING