SOCS 1 / 3 regulates the differentiation of T cells by inhibiting stat 3 and maybe related to Hashimoto ’ s thyroiditis

@inproceedings{Yang2017SOCS1,
  title={SOCS 1 / 3 regulates the differentiation of T cells by inhibiting stat 3 and maybe related to Hashimoto ’ s thyroiditis},
  author={Zhifang Yang and Jiazhen Tang and Shou Yuan and Meng Dai and Yanlu Yu and Yinglin Zheng},
  year={2017}
}
Objective: This study aims to explore the regulation of suppressor of cytokine signaling (SOCS1/3) on the differentiation of T cell and the role in Hashimoto’s thyroiditis (HT). Methods: The CD4+ T lymphocytes and B lymphocytes were separated from HT patients. The expression levels of SOCS1 and SOCS3 in CD4+ T cells were up-regulated using gene transfection technique, signal transducer and activator of transcription 3 (STAT3) was silenced simultaneously. They were co-cultured with B cells and… CONTINUE READING