SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells.

@article{Liu2012SNX2112AH,
  title={SNX-2112, an Hsp90 inhibitor, induces apoptosis and autophagy via degradation of Hsp90 client proteins in human melanoma A-375 cells.},
  author={Kai-Sheng Liu and Hui Liu and Jin-Huan Qi and Qiu-yun Liu and Zhong Liu and Min Xia and Guo-Wen Xing and Shao-xiang Wang and Yi-fei Wang},
  journal={Cancer letters},
  year={2012},
  volume={318 2},
  pages={180-8}
}
SNX-2112 is an Hsp90 inhibitor which is currently undergoing multiple phase 1 clinical trials; however, its mechanism of action needs to be further elaborated. Here we investigated the effects of SNX-2112 in A-375 cells. SNX-2112 induced the degradation of multiple Hsp90 client proteins, activated both the mitochondrial-mediated and death receptor-mediated apoptotic pathways, downregulated Bcl-2 and Bcl-xL, upregulated Bid, cleaved caspase-9, caspase-7, caspase-3 and PARP, and activated caspase… CONTINUE READING

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