SNT-1/FRS2α physically interacts with Laloo and mediates mesoderm induction by fibroblast growth factor

@article{Hama2001SNT1FRS2PI,
  title={SNT-1/FRS2α physically interacts with Laloo and mediates mesoderm induction by fibroblast growth factor},
  author={Joanne Hama and Hong Xu and Mitchell Goldfarb and Daniel C Weinstein},
  journal={Mechanisms of Development},
  year={2001},
  volume={109},
  pages={195-204}
}
Members of the fibroblast growth factor (FGF) ligand family play a critical role in mesoderm formation in the frog Xenopus laevis. While many components of the signaling cascade triggered by FGF receptor activation have been identified, links between these intracellular factors and the receptor itself have been difficult to establish. We report here the characterization of Xenopus SNT-1 (FRS2a), a scaffolding protein previously identified as a mediator of FGF activity in other biological… CONTINUE READING

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