SNRPN methylation patterns in germ cell tumors as a reflection of primordial germ cell development.

@article{Bussey2001SNRPNMP,
  title={SNRPN methylation patterns in germ cell tumors as a reflection of primordial germ cell development.},
  author={Kimberly J Bussey and Helen J. Lawce and Eleanor Himoe and Xiao-Ou Shu and Nyla A. Heerema and Elizabeth J Perlman and Susan B. Olson and R. Ellen Magenis},
  journal={Genes, chromosomes & cancer},
  year={2001},
  volume={32 4},
  pages={342-52}
}
Studies examining altered imprinted gene expression in cancer compare the observed expression pattern to the normal expression pattern for a given tissue of origin, usually the somatic expression pattern for the imprinted gene. Germ cell tumors (GCTs), however, require a developmental stage-dependent comparison. To explore using methylation as an indicator of germ cell development, we determined the pattern of methylation at the 5' untranslated region of SNRPN in 89 GCTs from both children and… CONTINUE READING

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