SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction.

@article{Nossent2011SNPsIM,
  title={SNPs in microRNA binding sites in 3'-UTRs of RAAS genes influence arterial blood pressure and risk of myocardial infarction.},
  author={Anne Ya{\"e}l Nossent and Jakob Lerche Hansen and Carine J. M. Doggen and Paul H A Quax and S\oren Paludan Sheikh and Frits R Rosendaal},
  journal={American journal of hypertension},
  year={2011},
  volume={24 9},
  pages={999-1006}
}
BACKGROUND We hypothesized that single nucleotide polymorphisms (SNPs) located in microRNA (miR) binding sites in genes of the renin angiotensin aldosterone system (RAAS) can influence blood pressure and risk of myocardial infarction. METHODS Using online databases dbSNP and TargetScan, we identified 10 SNPs in potential miR binding sites in eight RAAS-related genes, common in Caucasians. We genotyped a large case-control study on myocardial infarctions, the Study of Myocardial Infarctions… CONTINUE READING

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