SNPGenie: estimating evolutionary parameters to detect natural selection using pooled next-generation sequencing data

@article{Nelson2015SNPGenieEE,
  title={SNPGenie: estimating evolutionary parameters to detect natural selection using pooled next-generation sequencing data},
  author={Chase W. Nelson and Louise H. Moncla and Austin L. Hughes},
  journal={Bioinformatics},
  year={2015},
  volume={31 22},
  pages={3709-11}
}
UNLABELLED New applications of next-generation sequencing technologies use pools of DNA from multiple individuals to estimate population genetic parameters. However, no publicly available tools exist to analyse single-nucleotide polymorphism (SNP) calling results directly for evolutionary parameters important in detecting natural selection, including nucleotide diversity and gene diversity. We have developed SNPGenie to fill this gap. The user submits a FASTA reference sequence(s), a Gene… CONTINUE READING

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