SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype

  title={SNP selection at the NAT2 locus for an accurate prediction of the acetylation phenotype},
  author={Audrey Sabbagh and Pierre Darlu},
  journal={Genetics in Medicine},
Purpose: Genetic polymorphisms in the N-acetyltransferase 2 gene determine the individual acetylator status, which influences both the toxicity and efficacy profile of acetylated drugs. Determination of an individual's acetylation phenotype prior to initiation of therapy, through DNA-based tests, should permit to improve therapy response and reduce adverse events. However, due to extensive linkage disequilibrium between markers within NAT2, the genotyping of closely spaced markers yields highly… CONTINUE READING

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