SNP profile within the human major histocompatibility complex reveals an extreme and interrupted level of nucleotide diversity.

@article{Gaudieri2000SNPPW,
  title={SNP profile within the human major histocompatibility complex reveals an extreme and interrupted level of nucleotide diversity.},
  author={Silvana Gaudieri and Roger L Dawkins and Kozo Habara and Jerzy K. Kulski and Takashi Gojobori},
  journal={Genome research},
  year={2000},
  volume={10 10},
  pages={1579-86}
}
The human major histocompatibility complex (MHC) is characterized by polymorphic multicopy gene families, such as HLA and MIC (PERB11); duplications; insertions and deletions (indels); and uneven rates of recombination. Polymorphisms at the antigen recognition sites of the HLA class I and II genes and at associated neutral sites have been attributed to balancing selection and a hitchhiking effect, respectively. We, and others, have previously shown that nucleotide diversity between MHC… CONTINUE READING
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The P 5 multicopy gene family in the MHC is related in sequence to human endogenous retroviruses HERVL and HERV16

  • J. K. Kulski, S. Gaudieri, H. Inoko, R. L. Dawkins
  • Immunogenetics
  • 1999
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