SNP identification in unamplified human genomic DNA with gold nanoparticle probes

@article{Bao2005SNPII,
  title={SNP identification in unamplified human genomic DNA with gold nanoparticle probes},
  author={Yijia P. Bao and Martin Huber and T Wei and Sudhakar S. Marla and James J. Storhoff and Uwe R. M{\"u}ller},
  journal={Nucleic Acids Research},
  year={2005},
  volume={33},
  pages={e15 - e15}
}
Single nucleotide polymorphisms (SNPs) comprise the most abundant source of genetic variation in the human genome. SNPs may be linked to genetic predispositions, frank disorders or adverse drug responses, or they may serve as genetic markers in linkage disequilibrium analysis. Thus far, established SNP detection techniques have utilized enzymes to meet the sensitivity and specificity requirements needed to overcome the high complexity of the human genome. Herein, we present for the first time a… CONTINUE READING

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