SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex

@article{Norman2004SNPHA,
  title={SNP haplotypes and allele frequencies show evidence for disruptive and balancing selection in the human leukocyte receptor complex},
  author={Paul J Norman and Mark A. Cook and B. Sean Carey and Christine V. F. Carrington and David Harding Verity and Kamran Hameed and Dan D. Ramdath and Dasnayanee Chandanayingyong and M. Leppert and Henry A. F. Stephens and Robert W. Vaughan},
  journal={Immunogenetics},
  year={2004},
  volume={56},
  pages={225-237}
}
The human leukocyte receptor complex (LRC) of Chromosome 19q13.4 encodes polymorphic and highly homologous genes that are expressed by cells of the immune system and regulate their function. There is an enormous diversity at the LRC, most particularly the variable number of killer cell immunoglobulin-like receptor (KIR) genes. KIR have been associated with several disease processes due to their interaction with polymorphic human leukocyte antigen class I molecules. We have assessed haplotype… CONTINUE READING

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