SNP-guided identification of monoallelic DNA-methylation events from enrichment-based sequencing data

@inproceedings{Steyaert2014SNPguidedIO,
  title={SNP-guided identification of monoallelic DNA-methylation events from enrichment-based sequencing data},
  author={Sandra Steyaert and Wim Van Criekinge and Ayla De Paepe and Simon L I J Denil and Klaas Mensaert and Katrien Vandepitte and Wim Vanden Berghe and Geert A Trooskens and Tim De Meyer},
  booktitle={Nucleic acids research},
  year={2014}
}
Monoallelic gene expression is typically initiated early in the development of an organism. Dysregulation of monoallelic gene expression has already been linked to several non-Mendelian inherited genetic disorders. In humans, DNA-methylation is deemed to be an important regulator of monoallelic gene expression, but only few examples are known. One important reason is that current, cost-affordable truly genome-wide methods to assess DNA-methylation are based on sequencing post-enrichment. Here… CONTINUE READING