SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease

@article{Du2011SNPAM,
  title={SNP and mRNA expression for glutathione peroxidase 4 in Kashin-Beck disease},
  author={Xiao Hong Du and Xiaoxia Dai and Rui Xia Song and Xiuzhen Zou and Wen Yan Sun and Xiaoyan Mo and Guang Lu Bai and Yongmin Xiong},
  journal={British Journal of Nutrition},
  year={2011},
  volume={107},
  pages={164 - 169}
}
Kashin-Beck disease (KBD) is a chronic endemic osteoarthropathy, which mainly occurs in West and Northeast China. Epidemiological studies suggest that Se deficiency is an important environmental factor for the incidence of KBD. Glutathione peroxidase 4 (GPx4) belongs to the glutathione peroxidase family, which is crucial for optimal antioxidant defences. Our purpose is to investigate the putative association between GPx4 polymorphisms and the risk of KBD. Restriction fragment length… 
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The genotype of rs713041 was found to be associated with the mild, severe and early-onset PE and the results suggest that rs71 3041 in GPx4 may play a key role in the pathogenesis of PE.
PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese
TLDR
The study results suggest that PPARGC1B is a novel susceptibility gene of KBD, and three SNPs rs1078324, rs4705372, and rs11743128 of PPAR GC1B gene were genotyped in 559 KBD patients and 467 health controls using Sequenom MassARRAY platform.
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TLDR
Results indicate that selenoprotein transcription profile is dysregulated in patients with KBD, and the expression of GPX3, DIO1, and TXNRD1 genes might be involved in the development of chondrocyte apoptosis by affecting antioxidant capacity.
The Importance of Se-Related Genes in the Chondrocyte of Kashin–Beck Disease Revealed by Whole Genomic Microarray and Network Analysis
TLDR
The qRT-PCR validation showed that four genes expressed similarly with the ones in the microarray transcriptional profiles of Selenium (Se) deficiency, which involved in many molecular functions, biological processes, and apoptosis pathway may play important roles in the pathogenesis of KBD.
ASSOCIATION OF GPX 4-718 C / T POLYMORPHISM WITH TOURETTE SYNDROME IN A CHINA POPULATION
TLDR
A potential role for GPX4 cannot be ruled out in TS genetic susceptibility and no statistical difference was found in the HRR result, indicating an unlikely association between GPx4-718C/T and TS in a China population.
Genome-wide copy number variation study and gene expression analysis identify ABI3BP as a susceptibility gene for Kashin–Beck disease
TLDR
The first genome-wide copy number variation study (GCNVS) of KBD totally involving 2,743 Chinese Han adults suggests that ABI3BP was a novel susceptibility gene for KBD.
CpG methylation of the GPX3 promoter in patients with Kashin-Beck Disease potentially promotes chondrocyte apoptosis.
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  • Medicine, Biology
    Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements
  • 2022
Exome sequencing identified FGF12 as a novel candidate gene for Kashin-Beck disease
TLDR
This study suggests that FGF12 was a susceptibility gene of KBD, and provides novel clues for revealing the pathogenesis ofKBD and the biological function of FGF 12.
Imbalance of dietary nutrients and the associated differentially expressed genes and pathways may play important roles in juvenile Kashin-Beck disease.
  • Y. Ning, Xi Wang, +7 authors Xiong Guo
  • Medicine
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  • 2018
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TLDR
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TLDR
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TLDR
The polymorphism of haplotype TGC is associated withKBD, and the correlation analysis based on single locus showed no significant association with KBD.
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TLDR
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TLDR
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TLDR
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TLDR
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