SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression

@article{Zill2004SNPAH,
  title={SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression},
  author={Peter Zill and Thomas C. Baghai and Peter Zwanzger and Cornelius Schuele and Daniela Eser and Rainer Rupprecht and H. J. M{\"o}ller and Brigitta Bondy and Manfred Ackenheil},
  journal={Molecular Psychiatry},
  year={2004},
  volume={9},
  pages={1030-1036}
}
Tryptophan hydroxylase (TPH), being the rate-limiting enzyme in the biosynthesis of serotonin plays a major role as candidate gene in several psychiatric disorders. Recently, a second TPH isoform (TPH2) was identified in mice, which was exclusively present in the brain. In a previous post-mortem study of our own group, we could demonstrate that TPH2 is also expressed in the human brain, but not in peripheral tissues. This is the first report of an association study between polymorphisms in the… CONTINUE READING
Highly Influential
This paper has highly influenced 11 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 121 extracted citations

Lack of association between TPH2 gene polymorphisms with major depressive disorder in multiethnic Malaysian population.

Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists • 2015
View 10 Excerpts
Highly Influenced

A population-based association study of candidate genes for depression and sleep disturbance.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2010
View 16 Excerpts
Highly Influenced

Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2012
View 4 Excerpts
Highly Influenced

Tryptophan Research in Panic Disorder

International journal of tryptophan research : IJTR • 2008
View 4 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 30 references

Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics • 2004

Structured Clinical Interview for DSM-IV-TR Axis I Disorders: Research Version, Patient Edition, SCID-I/P

MB First, RL Spitzer, M Gibbon, JBW. Williams
2002

Similar Papers

Loading similar papers…