SNP analysis of Rac1 For personalized ligand interaction

  title={SNP analysis of Rac1 For personalized ligand interaction},
  author={Norbert Maggi and Patrizio Arrigo and Carmelina Ruggiero},
  journal={2010 Annual International Conference of the IEEE Engineering in Medicine and Biology},
This paper addresses mutational events that give rise to differing response to drugs focusing on Rac1, a protein that has been recognized as a target for drug design for cardiovascular disease due its regulatory role of angiogenesis. Rac1 has been considered with reference to Single Nucleotide Polymorphism (SNP), which has become of great value for personalized medicine. We have considered four variation of Rac1 registered in UNIPROTKB. Two of these variations are due to the environmental or… CONTINUE READING


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