SNP-SNP interactions in breast cancer susceptibility

  title={SNP-SNP interactions in breast cancer susceptibility},
  author={Ven{\"u}s {\"U}mmiye Onay and Laurent Briollais and J. A. G. Knight and Ellen Shi and Yuanyuan Wang and Sean Wells and Hong Li and Isaac Rajendram and Irene L Andrulis and Hilmi Ozçelik},
  journal={BMC Cancer},
  pages={114 - 114}
Breast cancer predisposition genes identified to date (e.g., BRCA1 and BRCA2) are responsible for less than 5% of all breast cancer cases. Many studies have shown that the cancer risks associated with individual commonly occurring single nucleotide polymorphisms (SNPs) are incremental. However, polygenic models suggest that multiple commonly occurring low to modestly penetrant SNPs of cancer related genes might have a greater effect on a disease when considered in combination. In an attempt to… CONTINUE READING


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