SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling

@article{Qin2017SNORA74BGS,
  title={SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling},
  author={Yi-yu Qin and Li Meng and Yang Fu and Zhiwei Quan and Mingzhe Ma and Ming-zhe Weng and Zhengdong Zhang and Cuixiang Gao and Xinghua Shi and Koulan Han},
  journal={Oncotarget},
  year={2017},
  volume={8},
  pages={19980 - 19996}
}
Small nucleolar RNAs (snoRNAs) have been implicated in the development of many cancers. We therefore examined the differential expression of snoRNAs between gallbladder cancer (GBC) tissues and matched adjacent non-tumor tissues using expression microarray analysis with confirmation by quantitative real-time PCR (qRT-PCR). Western blot analysis showed that SNORA74B levels were higher in GBC than non-tumor tissues. SNORA74B expression was positively associated with local invasion, advanced TNM… Expand
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