SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection.

@article{Joshi2013SNEDDSCF,
  title={SNEDDS curcumin formulation leads to enhanced protection from pain and functional deficits associated with diabetic neuropathy: an insight into its mechanism for neuroprotection.},
  author={Rayanta P. Joshi and Geeta Negi and Ashutosh Kumar and Yogesh Bapurao Pawar and Bhushan Munjal and Arvind K Bansal and Shyam Sunder Sharma},
  journal={Nanomedicine : nanotechnology, biology, and medicine},
  year={2013},
  volume={9 6},
  pages={776-85}
}
UNLABELLED Curcumin has shown to be effective against various diabetes related complications. However major limitation with curcumin is its low bioavailability. In this study we formulated and characterized self nano emulsifying drug delivery system (SNEDDS) curcumin formulation to enhance its bioavailability and then evaluated its efficacy in experimental diabetic neuropathy. Bioavailability studies were performed in male Sprague Dawley rats. Further to evaluate the efficacy of formulation in… CONTINUE READING