SNCG gene silencing in gallbladder cancer cells inhibits key tumorigenic activities.

@article{Han2012SNCGGS,
  title={SNCG gene silencing in gallbladder cancer cells inhibits key tumorigenic activities.},
  author={Shenghua Han and Feifei She and Dongfang Wang and Xiangqing Yao and Lei Jiang and Yanling Chen},
  journal={Frontiers in bioscience},
  year={2012},
  volume={17},
  pages={
          1589-98
        }
}
We recently determined that synuclein-gamma (SNCG) is highly expressed in human gallbladder cancer (GBC), and its abnormal expression is associated with tumor aggressiveness. To investigate the effects of SNCG gene silencing on the tumorigenic profiles of the GBC cell line, NOZ, short-hairpin RNA (shRNA) interference was employed. Specifically, the SNCG transcript was targeted by SNCG-shRNA lentiviral particles designed to silence SNCG gene expression. Following selection of NOZ cells stably… CONTINUE READING

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