SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.

  title={SNCA polymorphisms, smoking, and sporadic Parkinson's disease in Japanese.},
  author={Yoshihiro Miyake and Keiko Tanaka and Wakaba Fukushima and Chikako Kiyohara and Satoshi Sasaki and Yoshio Tsuboi and Tatsuo Yamada and Tomoko Oeda and Hiroyuki Shimada and Nobutoshi Kawamura and Nobutaka Sakae and Hidenao Fukuyama and Yoshio Hirota and Masaki Nagai},
  journal={Parkinsonism & related disorders},
  volume={18 5},
Several case-control studies and genome-wide association studies have examined the relationships between single nucleotide polymorphisms (SNPs) in the SNCA gene and Parkinson's disease (PD), and have provided inconsistent results. We investigated the relationships between SNPs rs356229, rs356219, rs356220, rs7684318, and rs2736990 and the risk of sporadic PD in Japan using data from a multicenter hospital-based case-control study. Included were 229 cases within 6 years of onset of PD as defined… CONTINUE READING