SNARE proteins contribute to calcium cooperativity of synaptic transmission.

@article{Stewart2000SNAREPC,
  title={SNARE proteins contribute to calcium cooperativity of synaptic transmission.},
  author={Bryan A Stewart and Mahmood Mohtashami and William S. Trimble and Gabrielle L Boulianne},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2000},
  volume={97 25},
  pages={13955-60}
}
A hallmark of calcium-triggered synaptic transmission is the cooperative relationship between calcium and the amount of transmitter released. This relationship is thought to be important for improving the efficiency of synaptic vesicle exocytosis. Although it is generally held that cooperativity arises from the interaction of multiple calcium ions with a single calcium-sensing molecule, the precise molecular basis of this phenomenon is not known. The SNARE proteins are known to be critical for… CONTINUE READING
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