SNARE proteins--why so many, why so few?

  title={SNARE proteins--why so many, why so few?},
  author={Michal Linial},
  journal={Journal of neurochemistry},
  volume={69 5},
Both trafficking and secretion critically depend on accurate and specific membrane recognition and fusion. A key step in these processes is the assembly of a complex consisting of a small number of proteins, i.e., the exocytic core complex. In nerve terminals, this set consists of VAMP and synaptotagmin, which reside at membranes of synaptic vesicles, and syntaxin and SNAP-25 at the plasma membrane. In this survey, different secretory systems that depend on the exocytic core proteins are… CONTINUE READING


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