SNARE proteins: one to fuse and three to keep the nascent fusion pore open.

@article{Shi2012SNAREPO,
  title={SNARE proteins: one to fuse and three to keep the nascent fusion pore open.},
  author={Lei Shi and Qing-Tao Shen and Alexander Kiel and Jing Wang and Hong-Wei Wang and Thomas J. Melia and James E Rothman and Frederic Pincet},
  journal={Science},
  year={2012},
  volume={335 6074},
  pages={1355-9}
}
Neurotransmitters are released through nascent fusion pores, which ordinarily dilate after bilayer fusion, preventing consistent biochemical studies. We used lipid bilayer nanodiscs as fusion partners; their rigid protein framework prevents dilation and reveals properties of the fusion pore induced by SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor). We found that although only one SNARE per nanodisc is required for maximum rates of bilayer fusion, efficient release… CONTINUE READING
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