SNARE proteins: one to fuse and three to keep the nascent fusion pore open.

  title={SNARE proteins: one to fuse and three to keep the nascent fusion pore open.},
  author={Lei Shi and Qing-Tao Shen and Alexander Kiel and Jing Wang and Hong-Wei Wang and Thomas J. Melia and James E Rothman and Frederic Pincet},
  volume={335 6074},
Neurotransmitters are released through nascent fusion pores, which ordinarily dilate after bilayer fusion, preventing consistent biochemical studies. We used lipid bilayer nanodiscs as fusion partners; their rigid protein framework prevents dilation and reveals properties of the fusion pore induced by SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor). We found that although only one SNARE per nanodisc is required for maximum rates of bilayer fusion, efficient release… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 9 times over the past 90 days. VIEW TWEETS


Publications citing this paper.
Showing 1-10 of 88 extracted citations


Publications referenced by this paper.


  • K. D. Brewer, W. Li, B. E. Horne, J. Rizo
  • Natl. Acad. Sci. U.S.A. 108,
  • 1272
2 Excerpts

Similar Papers

Loading similar papers…