SNARE-mediated trafficking of alpha5beta1 integrin is required for spreading in CHO cells.

@article{Skalski2005SNAREmediatedTO,
  title={SNARE-mediated trafficking of alpha5beta1 integrin is required for spreading in CHO cells.},
  author={Michael Skalski and Marc G. Coppolino},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={335 4},
  pages={1199-210}
}
In this study, the role of SNARE-mediated membrane traffic in regulating integrin localization was examined and the requirement for SNARE function in cellular spreading was quantitatively assessed. Membrane traffic was inhibited with the VAMP-specific catalytic light chain from tetanus toxin (TeTx-LC), a dominant-negative form (E329Q) of N-ethylmaleimide-sensitive fusion protein (NSF), and brefeldin A (BfA). Inhibition of membrane traffic with either E329Q-NSF or TeTx-LC, but not BfA… CONTINUE READING

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