SNARE-mediated membrane traffic modulates RhoA-regulated focal adhesion formation.

@article{Gonon2005SNAREmediatedMT,
  title={SNARE-mediated membrane traffic modulates RhoA-regulated focal adhesion formation.},
  author={Eva M Gonon and Michael Skalski and Michelle J. Kean and Marc G. Coppolino},
  journal={FEBS letters},
  year={2005},
  volume={579 27},
  pages={6169-78}
}
In the present study, we examined the role of soluble NSF attachment protein receptor (SNARE)-mediated membrane traffic in the formation of focal adhesions during cell spreading. CHO-K1 cells expressing a dominant-negative form of N-ethylmaleimide-sensitive factor (E329Q-NSF) were unable to spread as well as control cells and they formed focal adhesions (FAs) that were larger than those in control cells. FA formation was impaired in cells transfected with a dominant-negative form of RhoA, but… CONTINUE READING