SNARE-ing the structures of Sec1/Munc18 proteins.

  title={SNARE-ing the structures of Sec1/Munc18 proteins.},
  author={Julia K. Archbold and Andrew E. Whitten and S H Hu and Brett M Collins and Jennifer L. Martin},
  journal={Current opinion in structural biology},
Membrane fusion is essential for cellular transport in eukaryotes. Abnormalities contribute to a wide range of diseases including diabetes and neurological disorders. A key regulator of SNARE-mediated membrane fusion is the Sec1/Munc18 (SM) protein family. Universal structural features of SM proteins have been identified that affect the way these interact with their partner Syntaxin SNARE proteins. Whilst the molecular basis for SM-regulated SNARE complex formation has been extensively studied… CONTINUE READING