SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission.

Neuronal communication relies on rapid and discrete intercellular signaling but neither the molecular mechanisms of the exocytotic machinery that define the timing of the action potential-evoked response nor those controlling the kinetics of transmitter release from single synaptic vesicles are known. Here, we investigate how interference with the putative… CONTINUE READING